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1. MHC class I are present on all except
- Platelets
- All nucleated cells
- RBCs
- WBCs
ANSWER c
Class I MHC molecules are expressed on all nucleated cells and platelets
The major histocompatibility complex (MHC) of genes consists of a linked set of genetic loci encoding many of the proteins involved in antigen presentation to T cells, most notably the MHC class I and class II glycoproteins (the MHC molecules) that present peptides to the T-cell receptor.
Classical MHC class I molecules are ubiquitously expressed on all mammalian cells including cells of epithelial origin while MHC class II molecules are selectively expressed on antigen-presenting cells (APC) including dendritic cells (DC), macrophages, and B cells.
2. HLA B27 is not seen in which of the following?
- Ankylosing spondylitis
- Reiter’s syndrome
- Rheumatoid arthritis
- Psoriatic arthritis
ANSWER c
HLA B27 is associated with Seronegative spondyloarthropathies
Seronegative spondyloarthropathies
P: Psoriatic arthritis
A: Ankylosing spondylitis (AS)
I: Inflammatory bowel disease arthritis
R: Reactive arthritis (Reiter syndrome)
Features
- Absence of serum auto-antibodies
- Associated with HLA B27 (MC AS)
- Onset before the age of 40 years
- Presence of uveitis, spine/large peripheral joint arthritis
3. The role played by Major Histocompatibility Complex 1 and 2
- Transduce the signal to T cells following antigen recognition
- Mediate immunogenic class switching
- Present antigens for recognition by T cell antigen receptors
- Enhance the secretion of cytokines
ANSWER c
The physiologic function of MHC molecules is to display peptide fragments of proteins for recognition by antigen-specific T cells
Class I MHC molecules are required to display antigens to CD8 T cells
Class II MHC molecules are required to display antigens to CD4 T cells.
4. Antigen presented along with HLA class II stimulate
- CD8 cell
- CD4 cell
- CD2 cell
- CD19 cell
ANSWER b
5. Major histocompatibility complex class I is seen on which of the following cell?
- Macrophages only
- All body cells
- B cell only
- All blood cells except erythrocytes
