- NEED HELP? CALL US NOW
- +919995411505
- [email protected]
Past Oral Pathology Questions And Answers
1. Multiple bilateral dentigerous cysts are seen in?
- Down’s syndrome
- Maroteaux lamy syndrome
- Teacher collin syndrome
- Gorlin Goltz syndrome
ANSWER B
- Mucopolysaccharidosis type VI (MPS VI), also known as MaroteauxLamy syndrome, is a progressive condition that causes many tissues and organs to enlarge, become inflamed or scarred, and eventually waste away (atrophy).
- Rare genetic disorder characterized by complete or partial lack of activity of the enzyme arylsulfatase B (also called N-acetylgalactosamine-4- sulfatase), encoded by the ARSB gene.
- Deficiency or absence of this enzyme activity leads to the accumulation of complex carbohydrates called glycosaminoglycans (previously known as mucopolysaccharides) in the body.
- Abnormal accumulation of mucopolysaccharides leads to progressive involvement of multiple organ systems.
- Some common symptoms include:
- Breathing problems
- Walking problems by age 10
- Bone and joint malformation
- Corneal clouding
- Heart problems
- Rounded and heavy facial features
- Stiff joints
- Short stature
- Vision and hearing problems
- Delayed or absent puberty
- The main dental findings of this syndrome include gingival hyperplasia, hypertrophy of the maxillary alveolar ridge, macroglossia, unerupted dentition, malocclusions and dentigerous cyst-like follicles.
2. COC is now called as?
- Odontogenic ghost cell tumor
- Dentinogenic ghost cell tumor
- Keratocystic odontogenic tumour
- A & C
ANSWER B
- Dentinogenic ghost cell tumor (DGCT), also known as odontogenic ghost cell tumor, is considered as a rare neoplastic variant of calcifying odontogenic cyst (COC).
- In 1962, COC was recognized as a distinct clinicopathological entity by Gorlin et al.
- In 1971, WHO included it under classification of histological typing of odontogenic tumor, jaw cyst and allied lesions .
- In 1981, Praetorious et al. classified COC into cystic and solid neoplastic type and the term DGCT has been proposed for the neoplastic type.
- In 1983, Shear used the term dentinoameloblastoma for it due to resemblance of the features to the ameloblastoma and dentinoid production.
- In 2005, WHO included both type of COC under tumors, renamed COC as calcifying cystic odontogenic tumor (CCOT) and retained the term DGCT for the neoplastic type
- WHO [2005] defined DGCT as a locally aggressive tumor that is histologically characterized by strands and islands of ameloblastoma like epithelial cells infiltrating into mature connective tissue.
- Lesion also consists of aberrant keratinization in form of ghost cells with some of ghost cells undergoing calcification and production of variable amounts of dysplastic dentin
- DGCT are of two types, extraosseous (peripheral) and intraosseous (central) type.
3. Standard treatment of ameloblastoma:
- Segmental resection with 1 cm of normal bone
- Enbloc resection
- Enucleation
- Enucleation with cauterization
ANSWER A
The therapeutic approach of ameloblastoma should be analyzed after a thorough analysis of different histological factors, clinical characteristics and behavior of the lesion. The most appropriate treatment is resection with a margin of 1-1.5 cm apparently unbound bone
4. The most common odontogenic cyst is?
- Primordial cyst
- Dentigerous cyst
- Radicular cyst
- Mucocele
ANSWER C
Radicular cysts may account for up to as many as 70% of all cystic jawbone lesions. These cysts are thought to be the end results of epithelial cell rests proliferating during inflammation of teeth with infected and necrotic pulp, and apical periodontitis
5. Adenomatoid odontogenic tumour is characterized histologically by?
- Duct like epithelium surrounding small foci of calcification
- Stellate shaped cells
- Stratified squamous epithelial cells
ANSWER A
- The histological typing of the WHO defined the AOT as a tumor of odontogenic epithelium with duct-like structures and with varying degrees of inductive change in the connective tissue.
- The tumor may be partly cystic, and in some cases the solid lesion may be present only as masses in the wall of a large cyst.
- Well circumscribed
- AOT is composed of epithelial cells: polyhedral or spindle-shaped or ameloblast like cells , arranged to form different patterns like island, sheets, strands, whorled mass, rosettes, duct-like pattern or convoluted pattern.
- One of the characteristic features is duct-like or tubular arrangement of ameloblast like cells (therefore the name AOT)
- The ameloblast like cells have nucleus arranged at the periphery away from the central space which may contain eosinophilic material.
- Amorphous eosinophilic material also may be found in the midst of cells arranged as nests.
- Foci of calcification also may be scattered throughout the tumor.
- Connective tissue is scanty.
- Rosettes of tumor cells Eosinophilic (amyloid-like) material Polyhedral cells arranged to form nests Duct-like structures lined by ameloblast-like cells
- Polyhedral cells arranged to form nests
- Within cellular areas are tubular or duct like structures - Lined by single row of columnar cells with nuclei polarized away from the lumen Ductlike structures lined by ameloblast-like cell
