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Heparin
| HEPARIN | ORAL ANTICOAGULANTS | |
| Route of administration | Parenteral (IV, SC) | Oral |
| Onset of action | Rapid | Delayed(1-3days) |
| Activity | In vitro and in vivo | In vivo only |
| MOA | Activates antithrombin III | Decrease Activation of II, VII, IX, X |
| Monitoring by | aPTT | PT |
| Antagonist | Protamine sulphate | Vit K1 |
| Placental barrier | Does not cross placenta | Fetal warfarin syndrome |
| Use | To initiate therapy | For maintenance |
Q. Heparin acts via activation of
A) Antithrombin III
B) Factor VIII
C) Factor II and X
D) Factor V
Ans: A
