Leukemia is mainly of 4 types:
Acute myeloblastic leukemia (AML)
Acute lymphoblastic leukemia (ALL)
Chronic myeloid leukemia (CML)
Chronic lymphocytic leukemia (CLL)
| Type |
Important features |
| AML |
- Malignant transformation of undifferentiated precursors of myeloid series
- WBC count upto 1 lakh/mm3
- More than 30% myeloblasts are present im blood and bone marrow
- Common in all ages
- Gingival hyperplasia is most common
|
| ALL |
- Malignant transformation of undifferentiated precursors of lymphoid series.
- WBC counts upto 1 lakh/mm3 with more than 30% of lymphoblasts
- Common in young adults and children
- Gingival hyperplasia is less common
|
| CLL |
- Malignant transformation of well differentiated cells of myeloid series
- Common in elder age group
- WBC count upto 5 lakh/mm3 with less than 10% of lymphoblasts
- Gingival hyperplasia is less common
|
| CML |
- Malignant transformation of well differentiated cells of myeloid series
- Common in middle age
- The most consistent chromosomal abnormality is Philadelphia chromosome involving the reciprocal translocation of parts of long arm of chromosome 22 to the long arm of chromosome 9
- An increase in basophils upto 10% is characteristic feature of CML
- WBC count is upto 5 lakh/mm3 with less than 10% of myeloblasts are seen
- Gingival hyperplasia is common
|
