1. Corticosteroids:
- Used as bridge therapy to reduce disease activity till slower acting DMARDs take effect
- Can be used as adjunctive therapy for active disease that persists despite treatment with DMARDs
2. Synthetic DMARDs:
- Methotrexate
- Sulfasalazine
- Leflunomide
- Hydroxychloroquine
- Minocycline
- Tofacitinib
3. Biological DMARDs:
- TNF alpha inhibitors: Etanercept, Infliximab, Adalimumab, Golimumab
- Co stimulation inhibitors: Abatacept, Belatacept
- IL-6 inhibitor: Tocilizumab, Sarilumab
- B cell sarilumab depleter: Rituximab
- IL-IR antagonist: Anakinra
Q. Which of the following DMARDs require liver function testing?
A) Methotrexate. ( AIIMS Nov 2016)
B) Infliximab
C) Abatacept
D) Cyclophosphamide
Ans: A , Methotrexate